NEUE® Luminous Hydrating Cream

NEUE® Luminous Hydrating Cream 50g

- Comprehensively inhibits the formation of melanin
- Antioxidant
- Whitens and brightens the skin
- Refreshing skin feel

Key Ingredients:

Skin Whitening Peptide HR (Whitesse HR)

- More effective and safer than hydroquinone
- Noticeable whitening effect, improves skin tone
- Significantly improves dark spots
- Inhibits acne
- Anti-aging, anti-glycation
- Soothing, anti-inflammatory
- Antioxidant

NMN (Nicotinamide Mononucleotide)

- High safety profile
- Prevents skin roughness and aging
- Reduces skin wrinkles
- Maintains skin elasticity and a bright complexion
- Ceramide II (Ceramide 2)

Able to capture and lock in moisture needed by the epidermis to keep it soft, smooth, and hydrated. Balances moisture, enhancing the skin's self-protection function

Niacinamide

- Vitamin B3
- Corrects uneven skin tone
- Reduces pigmentation
- Effectively protects against UV damage
- Maintains healthy, beautiful skin
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NEUE® products contain:

- NMN (Nicotinamide Mononucleotide)
- Skin Whitening Agent HR (Whitesse HR)
- Majestem®

NMN (Nicotinamide Mononucleotide)

- High safety profile
- Prevents skin roughness and aging
- Reduces skin wrinkles
- Maintains skin elasticity and a bright complexion

The latest anti-aging NMN β-Nicotinamide Mononucleotide

Drives The Origin of Cellular Life

NMN (β-Nicotinamide Mononucleotide) is a naturally occurring bioactive nucleotide. It exists in two irregular forms, α and β; the β-isomer is the active form of NMN, with a molecular weight of 334.221 g/mol. The commonly used NMN refers to this form.

NMN is a precursor to coenzyme 1 NAD+ (Nicotinamide Adenine Dinucleotide) and can appropriately prolong life. The real anti-aging effect comes from another important energy metabolite called Nicotinamide Adenine Dinucleotide (NAD+).

As a nutrient, NMN is converted into NAD+ in cells. It is classified as a new type of Vitamin B3 and surpasses the effects of ordinary vitamins, considered a supplement for preventing aging and restoring youth.

NEUE brand is committed to anti-aging efficacy "combining the raw material technology and formula application of engineers." NMN skincare products can quickly lead the forefront in the cosmetic industry.

NMN - Efficacy Research

1. Regulates NAD+/NADH balance, protects human keratinocytes

Human keratinocytes were stimulated with ammonium ferric citrate (FAC) to induce cell death. Treatment with NMN, in comparison to the FAC group, effectively regulated the NAD+/NADH balance, reduced the rate of cell death, and increased the levels of glutathione (GSH) in the cells. This demonstrates that NMN can effectively regulate the NAD+/NADH balance, repair human keratinocytes, and enhance the cell's antioxidant capacity.

2. NMN defends against skin photoaging, repairs damage

Ultraviolet radiation (UV) causes significant changes in skin tissue morphology, such as epidermal thickening and an increased number of inflammatory cells.

After intraperitoneal injection of NMN, the thickness of the epidermis and dermis in mice was almost consistent with that of the blank control; the number of hypertrophic cells under UV stimulation was significantly reduced.

NMN can defend against the damage to the skin caused by ultraviolet rays.

3. NMN enhances antioxidant and anti-glycation abilities

Using a mouse model (injection), NMN has been validated to enhance antioxidant and anti-glycation capabilities. Ultraviolet B (UVB) radiation induces oxidative stress in the skin, raising the levels of oxygen free radicals and reducing the levels of antioxidant enzymes.

Changes in various antioxidant and anti-glycation-related indicators were observed in the NMN-treated group: Total superoxide dismutase (T-SOD) and catalase (CAT) levels increased, while levels of hydrogen peroxide (H2O2) and advanced glycation end-products (AGEs) decreased.

This indicates that NMN can effectively improve the skin's antioxidant and anti-glycation abilities.

4. NMN downregulates pro-inflammatory factors, reducing inflammation

Through a mouse model (injection), NMN has been validated to regulate the balance of cellular inflammatory factors. Compared to the ultraviolet B (UVB) group, treatment with NMN significantly decreased the levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in the skin tissue, while the levels of anti-inflammatory cytokines IL-4 and IL-10 were significantly increased. This indicates that NMN can regulate the balance of cellular inflammation, reduce skin inflammation, and thus defend against skin damage and aging caused by inflammation.


5. NMN reduces skin inflammation and edema, repairs the skin barrier

Through validation with a mouse model, the application of 2,4-dinitrofluorobenzene induced specific dermatitis in the mice, resulting in symptoms such as redness, swelling, and peeling. After topically applying 5% NMN and 0.05% dexamethasone to the mouse skin for 14 days, there was a noticeable improvement in the dermatitis symptoms, a reduction in skin swelling, a decrease in transepidermal water loss, and skin repair, with the effects of NMN being more pronounced.

6. NMN clears reactive oxygen species (ROS)

Reactive oxygen species (ROS) within cells are one of the direct causes of oxidative damage to cells and an important marker of cell apoptosis. The level of ROS is negatively correlated with the content of collagen fibers. Reducing the amount of ROS inside cells is an effective and important way to combat aging and oxidative stress.

This experiment, through a UV radiation model, explored the effect of NMN on ROS within human keratinocytes. The results showed that after UV exposure, the internal ROS levels in the cells significantly increased. Administration of NMN at concentrations of 50ppm, 100ppm, and 200ppm effectively inhibited the synthesis of ROS, demonstrating antioxidant effects.

NMN - Safety

- Safety tests such as skin and eye irritation have been conducted.
- NMN is a naturally occurring bioactive nucleotide and is an innate substance in the human body.
- NMN as an oral food has been permitted abroad and has been used in health foods and cosmetics in countries like the United States, Japan, and Canada, with many years of usage history.


Skin Whitening Agent HR (Whitesse HR)

- A powerful and extremely safe skin whitening agent
- Acts on six positions in the melanin production pathway
- Multiple clinical tests have proven its effect to be four times that of hydroquinone
- Significant whitening effect, improves skin tone, significantly improves dark spots
- Inhibits acne
- Anti-aging, anti-glycation
- Soothing, anti-inflammatory
- Antioxidant

HR (Whitesse HR) - Efficacy Research

1. Used by most major multinational companies as a key whitening ingredient

According to reports, HR is an excellent inhibitor of polyphenol oxidase (PPO), which is the main cause of enzymatic browning in fruits and vegetables. Tests have shown that HR has the best inhibitory effect on the browning of apple juice.

2. Improves acne damage, pH, average pore diameter, and number of pores

3. Significantly improves dark spots

HR (Whitesse HR) - Safety

- HR can be applied to food
- GRAS certification by the UK FDA
- Food additive published by the World Health Organization
- A long history of human use

Majestem® from the precious Edelweiss flower in the snowy mountains

- Tightens sagging neck skin
- Lifts cheeks
- Smooths crow's feet wrinkles

Majestem™ is an active ingredient obtained through Sederma's patented HTN™ (plant cell culture) technology, providing a visibly significant lift and firming effect on the skin. Born from nobility, extracted from the very rare and strictly protected mountain Edelweiss (also known as snow fluff).

Award-winning

The HTN™ technology can efficiently and specifically obtain target active molecules; the active concentration of leontopodic acid from Majestem™ is 500ppm without preservatives.

Majestem® - Efficacy Research

1. Fibroblast contraction ability weakened VS restoration of contraction ability

Our skin becomes lax, largely because matrix metalloproteinases (MMPs) are synthesized in significant amounts in the skin, damaging the collagen fibers (the cell's framework).

However, Majestem™ can stimulate the production of TIMPs (tissue inhibitors of metalloproteinases), while also promoting the production of collagen, protecting the extracellular matrix (ECM), and possessing the ability to repair mitochondrial vitality. This improves the contractile ability of fibroblasts.

2. Creates a firm little V-face

In just 3 weeks, Majestem™ tightens and lifts sagging neck skin, reshaping a youthful neck contour.

3. Noticeable neck wrinkle smoothing effect

Matrix metalloproteinases (MMPs) are synthesized in large amounts in the skin, causing damage to collagen fibers (the cellular framework).

However, Majestem™ can stimulate the production of tissue inhibitors of metalloproteinases (TIMPs), while also promoting the production of collagen, protecting the extracellular matrix (ECM), and possessing the ability to repair mitochondrial vitality, leading to improved contractile ability of fibroblasts.